Subacute toxicity studies in dogs for 4 weeks at 480 mg/kg each day confirmed no distinct improvements; at 960 mg/kg, two away from 8 died with evidence of circulatory collapse. This broad margin of safety is critical when compared with chlordiazepoxide HCl, which showed nonspecific alterations in 6 dogs at eighty mg/kg.Bodily, SAR functions is usu